The effects of α-tocopherol on site-specific lipid peroxidation induced by iron in charged micelles

  • Fukuzawa K
  • Kishikawa K
  • Tadokoro T
 et al. 
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Abstract

α-Tocopherol inhibited H2O2-Fe2+-induced lipid peroxidation of linoleic acid (LA) by scavenging OH radicals in tetradecyltrimethylammonium bromide (TTAB) micelles. The inhibiting ability of α-tocopherol was much greater than that of OH-radical scavengers mannitol and t-butanol. In contrast, α-tocopherol enhanced linoleic acid hydroperoxide (LOOH)Fe2+-induced lipid peroxidation through regeneration of Fe2+in sodium dodecyl sulfate (SDS) micelles containing LA. α-Tocopherol was oxidized by Fenton's reagent (FeSO4+ H2O2) at a higher rate in SDS micelles than in TTAB micelles. The likely oxidants were OH radicals in the former and Fe3+in the latter. Both reagents formed in the Fenton reaction. Ferrous ion catalyzed in a dose-dependent manner the decomposition of LOOH and conjugated diene compounds in SDS but not in TTAB micelles. α-Tocopherol and Fe3+individually had no effect on the decomposition of LOOH, but together were quite effective. The rate of the decomposition was a function of the concentration of α-tocopherol. The mechanism of "site-specific" antioxidant action of α-tocopherol in charged micelles is discussed. © 1988.

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Authors

  • Kenji Fukuzawa

  • Katsuya Kishikawa

  • Toyohiro Tadokoro

  • Akira Tokumura

  • Hiroaki Tsukatani

  • Janusz M. Gebicki

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