The effects of α-tocopherol on site-specific lipid peroxidation induced by iron in charged micelles

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Abstract

α-Tocopherol inhibited H2O2-Fe2+-induced lipid peroxidation of linoleic acid (LA) by scavenging OH radicals in tetradecyltrimethylammonium bromide (TTAB) micelles. The inhibiting ability of α-tocopherol was much greater than that of OH-radical scavengers mannitol and t-butanol. In contrast, α-tocopherol enhanced linoleic acid hydroperoxide (LOOH)Fe2+-induced lipid peroxidation through regeneration of Fe2+in sodium dodecyl sulfate (SDS) micelles containing LA. α-Tocopherol was oxidized by Fenton's reagent (FeSO4+ H2O2) at a higher rate in SDS micelles than in TTAB micelles. The likely oxidants were OH radicals in the former and Fe3+in the latter. Both reagents formed in the Fenton reaction. Ferrous ion catalyzed in a dose-dependent manner the decomposition of LOOH and conjugated diene compounds in SDS but not in TTAB micelles. α-Tocopherol and Fe3+individually had no effect on the decomposition of LOOH, but together were quite effective. The rate of the decomposition was a function of the concentration of α-tocopherol. The mechanism of "site-specific" antioxidant action of α-tocopherol in charged micelles is discussed. © 1988.

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Fukuzawa, K., Kishikawa, K., Tadokoro, T., Tokumura, A., Tsukatani, H., & Gebicki, J. M. (1988). The effects of α-tocopherol on site-specific lipid peroxidation induced by iron in charged micelles. Archives of Biochemistry and Biophysics, 260(1), 153–160. https://doi.org/10.1016/0003-9861(88)90436-5

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