Effects of 2-Amino-7-phosphonoheptanoic acid on EEG of rats

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2-APH is an antagonist of excitation due to dicarboxylic amino acids and has a protective effect against several types of experimental seizures. We have studied its effect on EEG of rats. Following either intracerebroventricular or intraperitoneal administration of 2-APH produces slow waves of high voltage in central cortex. The anticonvulsant action of this drug may be related to altered activity in neurones of this area. ?? 1985.




Rostain, J. C., Wardley-Smith, B., & Meldrum, B. S. (1985). Effects of 2-Amino-7-phosphonoheptanoic acid on EEG of rats. Electroencephalography and Clinical Neurophysiology, 60(4), 367–369. https://doi.org/10.1016/0013-4694(85)90010-0

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