Effects of 2-Amino-7-phosphonoheptanoic acid on EEG of rats

  • Rostain J
  • Wardley-Smith B
  • Meldrum B
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Abstract

2-APH is an antagonist of excitation due to dicarboxylic amino acids and has a protective effect against several types of experimental seizures. We have studied its effect on EEG of rats. Following either intracerebroventricular or intraperitoneal administration of 2-APH produces slow waves of high voltage in central cortex. The anticonvulsant action of this drug may be related to altered activity in neurones of this area. ?? 1985.

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