Effects of the 5-HT uptake inhibitors, femoxetine and paroxetine, and a 5-HT1A/Bagonist, eltoprazine, on the behavioural satiety sequence

  • McGuirk J
  • Muscat R
  • Willner P
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Abstract

In rats allowed access to a 35% sucrose solution, following a 4-h period of food and water deprivation, an initial period of sucrose consumption was followed by a short period of grooming and exploratory behaviour, later superseded by resting. This "behavioural satiety sequence" was advanced in time by the 5-HT uptake inhibitors femoxetine and paroxetine and by the 5-HT1A/Bagonist eltoprazine at anorectic and subanorectic doses. These effects, which are similar to those previously observed with another 5-HT uptake inhibitor, fluoxetine, are compatible with an increase in postprandial satiety. © 1992.

Author-supplied keywords

  • 5-HT uptake inhibitors
  • 5-HT1receptors
  • Behavioural satiety sequence
  • Eltoprazine
  • Femoxetine
  • Paroxetine
  • Rat

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