Effects of hyperlipidemias in hamsters on lipid transfer protein activity and unidirectional cholesteryl ester transfer in plasma

  • Quig D
  • Arbeeny C
  • Zilversmit D
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Abstract

Experiments were performed to characterize plasma lipid transfer protein activity (LTA), and the rate of [3H]CE transfer from HDL to lower density lipoproteins in plasma of hamsters. Compared to rabbits, hamster plasma has about one-tenth the level of d > 1.21 LTA but a relatively high level of VLDL-triacylglycerols, and a higher fractional rate of HDL-[3H]CE transfer in plasma (in vitro) than predicted by the d > 1.21 LTA. Like the rat, hamster plasma contains an inhibitors(s) of LTA; the level of the inhibitor activity in d > 1.21 g/ml plasma was similar in normal and hyperlipoproteinemic hamsters. Hypertriglyceridemia in sucrose-fed hamsters did not affect LTA, cholesteryl ester transfer or the plasma level of HDL-CE. However, a comparable degree of hypercholesterolemia was associated with a 122% increase in plasma d > 1.21 LTA and a 63% increase in the fractional rate of [3H]CE transfer from HDL to lower density lipoproteins in plasma. Cholesterol feeding in hamsters was associated with increased plasma levels of LDL-cholesterol and, to a lesser extent, with VLDL- and IDL-cholesterol. © 1991.

Author-supplied keywords

  • Apolipoprotein
  • Cholesterol-feeding
  • Hypercholesterolemia
  • Hypertriglyceridemia

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Authors

  • David W. Quig

  • Cynthia M. Arbeeny

  • Donald B. Zilversmit

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