The effects of intravenous administration of cholecystokinin on feeding behaviour and release of pituitary hormones in pigs are not mediated by serotonergic (5-HT3) receptors

  • Parrott R
  • Ebenezer I
  • Forsling M
  • 3


    Mendeley users who have this article in their library.
  • 4


    Citations of this article.


Two experiments were carried out using the serotonergic (5-HT3) antagonist ondansetron (GR 38032F) to investigate whether the actions of peripherally-administered cholecystokinin octapeptide (CCK) in the prepubertal pig might involve 5-HT3receptors. In Experiment 1, it was shown that ondansetron (10 or 30 mg, i.v.) did not affect the initial feeding response and did not modify the behavioural inhibition induced by a subsequent injection of CCK (1.3 μg/kg, i.v.). In Experiment 2, it was demonstrated that the nauseogenic action of CCK, indicated by its stimulatory effect on release of vasopressin and Cortisol, was not markedly altered by ondansetron (30 mg, i.v.). These results suggest that 5-HT3receptors play a negligible part in mediating the behavioural and endocrine responses induced by bolus intravenous injections of CCK in this species. © 1992.

Author-supplied keywords

  • 5-HT3receptor antagonism
  • CCK
  • cortisol
  • feeding
  • pigs
  • vasopressin

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • R. F. Parrott

  • I. S. Ebenezer

  • M. L. Forsling

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free