Effects of penicillin and silymarin on liver enzymes and blood clotting factors in dogs given a boiled preparation of Amanita phalloides

Abstract

Dogs were given sublethal doses of Amanita phalloides (death cap), and liver injury, a major feature of this intoxication, was monitored by serum enzymes and coagulation factors. The tested antidotes were selected from an array of agents which had shown some antagonism to death cap toxins in previous experiments performed with mice and rats. Penicillin G and silymarin prevented the rise of liver enzymes in the blood of the intoxicated dogs and the fall of clotting factors. Cytochrome c, prednisolone, and cimetidine failed to be effective. © 1978.