Effects of stress and ebiratide (Hoe-427) on free-choice ethanol consumption: Comparison of lewis and Sprague-Dawley rats

18Citations
Citations of this article
6Readers
Mendeley users who have this article in their library.
Get full text

Abstract

The effects of immobilization stress, isolation stress and administration of Hoe-427 on free-choice consumption of ethanol by Lewis and Sprague-Dawley rats were studied. The animals were offered two-bottle choice consumption of 0.2% saccharin and 10% ethanol/0.2% saccharin, then exposed to 4 days of immobilization stress or isolation stress on an irregular, unpredictable schedule or 4 days of i.p. doses of Hoe-427 at 1800 hours. Both stresses resulted in significant decreases in ethanol consumption during the stress period. Hoe-427 produced a significant decrease in ethanol consumption, in a dose-dependent manner. Saccharin consumption was not significantly affected by any of the treatments. The ability to correlate the Lewis and Sprague-Dawley rat response further aids in supporting the role of the adrenocorticotropic peptide in the development of ethanol consumption. © 1994.

Cite

CITATION STYLE

APA

Sprague, J. E., & Maickel, R. P. (1994). Effects of stress and ebiratide (Hoe-427) on free-choice ethanol consumption: Comparison of lewis and Sprague-Dawley rats. Life Sciences, 55(11), 873–878. https://doi.org/10.1016/0024-3205(94)90043-4

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free