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Abstract

Treatment with trimethyltin (TMT) induced atrophy of the thymus, spleen and lymph nodes within 2 days, but no changes in the bone marrow were observed. Atrophy of thymus and spleen did not occur in adrenal-ectomized rats treated with TMT. Antibody responses to sheep erythrocytes (SRBC) and proliferative responses of spleen lymphocytes to phytohemagglutinin (PHA), concanavalin A (ConA) and lipopolysaccharides (LPS) were suppressed significantly in treated rats. Delayed hypersensivity to oxazalone, natural killer (NK) cell activity and the phagocytic activity of peritoneal macrophages (PEM) were not affected significantly. © 1984.

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Hioe, K. M., & Jones, J. M. (1984). Effects of trimethyltin on the immune system of rats. Toxicology Letters, 20(3), 317–323. https://doi.org/10.1016/0378-4274(84)90166-8

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