Effects of trimethyltin on the immune system of rats

  • Hioe K
  • Jones J
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Treatment with trimethyltin (TMT) induced atrophy of the thymus, spleen and lymph nodes within 2 days, but no changes in the bone marrow were observed. Atrophy of thymus and spleen did not occur in adrenal-ectomized rats treated with TMT. Antibody responses to sheep erythrocytes (SRBC) and proliferative responses of spleen lymphocytes to phytohemagglutinin (PHA), concanavalin A (ConA) and lipopolysaccharides (LPS) were suppressed significantly in treated rats. Delayed hypersensivity to oxazalone, natural killer (NK) cell activity and the phagocytic activity of peritoneal macrophages (PEM) were not affected significantly. © 1984.

Author-supplied keywords

  • Organotin
  • adrenal
  • immunity
  • thymus

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  • Kiem M. Hioe

  • Joe M. Jones

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