Effects of ultrasound on the steady-state transmembrane pH gradient and the permeability of acetic acid through bilayer lipid membranes

  • Pohl P
  • Rosenfeld E
  • Millner R
  • 5


    Mendeley users who have this article in their library.
  • 28


    Citations of this article.


The irradiation of bilayer lipid membranes with continuous ultrasound of a frequency of 8.2 MHz and a special peak time average (SPTA) intensity of 0.4 W/cm2reduces the thickness of the unstirred layer up to 40% of its initial value under our conditions. This result was obtained from measurements of the transmembrane potential which appears after the addition of a protonophore in the presence of a gradient of acetic acid. Ultrasound exposure decreases this potential when the pH of the buffer solutions is much higher than the pK of CH3COOH and has no effect at low pH values. The latter can be explained by a simultaneous increase of the permeability of acetic acid and the buffer substances, respectively, due to ultrasound irradiation. © 1993.

Author-supplied keywords

  • Bilayer lipid membrane
  • Protonophore
  • Ultrasound
  • Unstirred layer
  • Weak acid

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • Peter Pohl

  • Eike Rosenfeld

  • Rudolf Millner

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free