An efficient process for the resolution of cis-4-O-protected-2-cyclopenten-1,4-diol using pancreatin lipase in [C8mim][PF6] as a reusable system

  • Das S
  • Chandrasekhar S
  • Yadav J
 et al. 
  • 2

    Readers

    Mendeley users who have this article in their library.
  • 7

    Citations

    Citations of this article.

Abstract

An efficient porcine pancreatin lipase-catalyzed transesterification of cis-4-O-TBS-2-cyclopenten-1,4-diol has been demonstrated in 1-octyl-3-methylimidazolium hexafluorophosphate, [C8mim][PF6] ionic liquid, furnishing both the alcohol and the corresponding acetate in excellent enantiomeric purity and yields. This typical reaction system containing the suspension of enzymes in ionic liquid medium could be reused up to five times to prepare the required products in consistent yields and ee's. The corresponding optically active derivatives are very useful intermediates towards the synthesis of various types of compounds, including prostanoids. © 2008 Elsevier Ltd. All rights reserved.

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Authors

  • Saibal Das

  • Srivari Chandrasekhar

  • Jhillu Singh Yadav

  • A. V. Rama Rao

  • René Grée

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free