Efficient synthesis of benzocyclohexanes via intramolecular Friedel-Crafts reaction of halogen free 6-acetoxy-4-alkenyl arenes

  • Ma S
  • Zhang J
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Abstract

Benzocyclohexane derivatives were prepared highly stereoselectively by the cyclic Friedel-Crafts reaction of 6-acetoxy-4-alkenyl arenes in moderate to excellent yields in TFA/HOAc (3:1). It was observed that the rate of the cyclization as well as the yields of products depend largely on the substituents of the allylic acetate moiety. © 2002 Elsevier Science Ltd. All rights reserved.

Author-supplied keywords

  • Allylations
  • Arenes
  • Carbocycles
  • Cyclizations
  • Heterocycles

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Authors

  • Shengming Ma

  • Junliang Zhang

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