Continuous ECoG, EMG and SP recordings were taken in rats prior and subsequent to ECS treatments. Slow-potential (SP) shifts associated with sleep and wakefulness were consistent in direction and predictable in occurrence before and after treatment. SP shifts accompanying the transition from quiet wakefulness to slow-wave sleep (SWS) and from SWS to paradoxical sleep (PS) were surface negative. Upon arousal, there was a positive shift to waking SP levels. A substantial increase in total sleep time (TST) accompanied by a reduction in PS persisted for 3 days following ECS. Thereafter, both TST and PS returned to baseline levels. A rebound in PS duration and frequency occurred at different times in different animals, but a significant overall rebound effect could not be demonstrated in the pooled data. All treatments elicited grand mal electrical and behavioral seizures. ECS-induced SP shifts were surface negative (4-8 mV) and lasted from 10-30 sec. In contrast to the SP stability prior to ECS, every animal underwent major aperiodic SP shifts after ECS. These were of greater magnitude and longer duration than those seen during pre-ECS sleep-wakefulness cycles. © 1977.
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