Electroencephalographic and behavioral effects of experimental porphyria in the rat

12Citations
Citations of this article
4Readers
Mendeley users who have this article in their library.
Get full text

Abstract

This investigation was made to assess the relationship of allylisopropylacetamide (AIA)-induced porphyria with changes in biochemical, behavioral and central nervous system function. The possible central effect of the porphyrin precursor δ-aminolevulinic acid (ALA) was also studied. EEG and behavior were observed and urine collected from freely moving female Long-Evans rats with chronically implanted cortical electrodes. A single dose of 400-500 mg/kg of AIA induced a reversible progression of EEG changes characteristics of CNS excitation and elevated urinary levels of ALA and porphobilinogen (PBG). Repeated daily injections of 400 mg/kg of AIA led to a progressive reduction in the duration and degree of EEG and behavioral changes and a reduction of porphyria. ALA, 400 mg/kg, did not produce any abnormal EEG or behavioral effects. © 1970.

Cite

CITATION STYLE

APA

Marcus, R. J., Wetterberg, L., Yuwiler, A., & Winters, W. D. (1970). Electroencephalographic and behavioral effects of experimental porphyria in the rat. Electroencephalography and Clinical Neurophysiology, 29(6), 602–607. https://doi.org/10.1016/0013-4694(70)90102-1

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free