Emetic activity of zacopride in ferrets and its antagonism by pharmacological agents

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Abstract

Zacopride administered orally was more emetic in fed than in fasted ferrets. The emetic activity of zacopride (0.1 mg/kg p.o.) was inhibited (100%) by 0.1 mg/kg i.p. of zacopride and 1 mg/kg i.p. of ICS 205-930. Haloperidol (3.16 mg/kg i.p.) and prochlorperazine (3.16 mg/kg i.p.) were weakly effective. N-acetyl-5-hydroxytryptophyl-5-hydroxytryptophan amide, a 5-HT1Pantagonist, was inactive. Thus, the emetic activity of zacopride, like that of cisplatin, is blocked by 5-HT3receptor antagonists. © 1990.

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Sancilio, L. F., Pinkus, L. M., Jackson, C. B., & Munson, H. R. (1990). Emetic activity of zacopride in ferrets and its antagonism by pharmacological agents. European Journal of Pharmacology, 181(3), 303–306. https://doi.org/10.1016/0014-2999(90)90094-M

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