Emetic activity of zacopride in ferrets and its antagonism by pharmacological agents

  • Sancilio L
  • Pinkus L
  • Jackson C
 et al. 
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Abstract

Zacopride administered orally was more emetic in fed than in fasted ferrets. The emetic activity of zacopride (0.1 mg/kg p.o.) was inhibited (100%) by 0.1 mg/kg i.p. of zacopride and 1 mg/kg i.p. of ICS 205-930. Haloperidol (3.16 mg/kg i.p.) and prochlorperazine (3.16 mg/kg i.p.) were weakly effective. N-acetyl-5-hydroxytryptophyl-5-hydroxytryptophan amide, a 5-HT1Pantagonist, was inactive. Thus, the emetic activity of zacopride, like that of cisplatin, is blocked by 5-HT3receptor antagonists. © 1990.

Author-supplied keywords

  • (Ferret)
  • (Oral)
  • 5-HT antagonists
  • Benzamides (zacopride)
  • Emesis

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Authors

  • Lawrence F. Sancilio

  • Lawrence M. Pinkus

  • Carlotta B. Jackson

  • H. Randall Munson

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