Enantioselective separation in capillary electrophoresis using a novel mono-6A-propylammonium-β-cyclodextrin as chiral selector

  • Tang W
  • Muderawan I
  • Ng S
 et al. 
  • 5


    Mendeley users who have this article in their library.
  • 28


    Citations of this article.


The chiral resolving ability of a novel single-isomer cationic β-cyclodextrin (CD), mono-6A-propylammonium-6A-deoxy-β-cyclodextrin chloride (PrAMCD), as a chiral selector in capillary electrophoresis (CE) is reported in this work for the enantioseparation of hydroxy, carboxylic acids and amphoteric analytes. The effect of chiral selector concentration on the resolution was studied. Good resolutions were achieved for hydroxy acids. Optimum resolutions were obtained even at 3.5 mM CD concentration for carboxylic acids. The electrophoretic method showed good linearity and reproducibility in terms of migration times and peak areas, which should make it suitable for routine analysis. In addition, baseline chiral separation of a six-acid mixture was achieved within 20 min. PrAMCD proved to be an effective chiral selector for acidic analytes. © 2005 Elsevier B.V. All rights reserved.

Author-supplied keywords

  • 6A-Propylammonium-6A-deoxy-β- cyclodextrin chloride
  • Capillary electrophoresis
  • Cationic β-cyclodextrin
  • Enantionmeric separation

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • Weihua Tang

  • I. Wayan Muderawan

  • Siu Choon Ng

  • Hardy Sze On Chan

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free