Enhancement of NAD-linked isocitrate dehydrogenase activity in rat liver by clofibrate feeding

  • Schön H
  • Kremser K
  • Prager C
 et al. 
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Abstract

After feeding rats for 3 weeks with clofibrate specific activities of the liver mitochondrial enzymes glycerol-3-phosphate dehydrogenase (G3PDH) and NAD-linked isocitrate dehydrogenase (NAD-ICDH) were found to be increased in a large particle fraction 6-fold and 1.6-fold, respectively, whereas the activity of NADP-linked isocitrate dehydrogenase (NADP-ICDH) remained unchanged. Possibly these effects contribute to the hypolipidemic action of clofibrate.

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Authors

  • Hans J. Schön

  • Karl Kremser

  • Christiane Prager

  • Robert Kramar

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