Enhancement of the water solubility of aromatic molecules via the heck reaction. A comparison of ethano-ammonium, carboxylate and -phosphonate functional groups

  • LaBrenz S
  • Bekele H
  • Kelly J
  • 3


    Mendeley users who have this article in their library.
  • 6


    Citations of this article.


The solubility of aromatic compounds in aqueous solution is difficult to predict due to the lack of systematic solubility data and the inherent difficulties associated with theoretical predictions. Synthetic methodology is introduced for incorporating an ethano-phosphonate solubilizing group into aromatics, which has been used previously to introduce ethano-carboxyl and ethano-amino groups into aromatics. The aqueous solubility of these derivatized aromatics were carefully evaluated at 25°C so that others may use this data to further develop prediction algorithms and make simple predictions regarding solubility.

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free