epi-Neoxaline, a chemotaxonomic marker for Penicillium tulipae

  • Overy D
  • Phipps R
  • Frydenvang K
 et al. 
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Penicillium tulipae was found to contain a metabolite comparable to neoxaline. Further studies investigating the in vitro and in planta prodn. of roquefortine/oxaline biosynthesis pathway metabolites demonstrated that meleagrin accumulated in the mycelia of P. tulipae, while the new metabolite, epi-neoxaline (I), was excreted into the surrounding environment. This led to the conclusion that epi-neoxaline is the end-product of the roquefortine/epi-neoxaline biogenesis pathway in P. tulipae. The chemotaxonomic significance of epi-neoxaline in P. tulipae was investigated by comparing the metabolite prodn. of 10 strains of each Corymbifera taxa. The results show that epi-neoxaline is an important chemotaxonomic marker for P. tulipae, as reflected in the consistent, reliable prodn. and ease with which this metabolite can be visualized using CeSO4 spray during TLC profiling. [on SciFinder (R)]

Author-supplied keywords

  • Chemotaxonomy
  • Meleagrin
  • Penicillium tulipae
  • Secondary metabolite profiling
  • epi-Neoxaline

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  • David P. Overy

  • Richard K. Phipps

  • Karla Frydenvang

  • Thomas O. Larsen

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