Evaluation of the stoichiometry and strength of chloroquine-porphyrin interactions by difference spectroscopy

  • Shanley B
  • Clarke K
  • Winzor D
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Abstract

Chloroquine [54-05-7] interacted with both uroporphyrin [26316-36-9] and coproporphyrin [14643-66-4], and plots of difference spectroscopy data indicated a 1:1 stoichiometry for both porphyrin-chloroquine complexes. Thus, the stoichiometry of the interaction was not affected by the presence of 4 carboxyl groups on coproporphyrin and 8 on uroporphyrin, although the strength of the interaction was ∼3-fold higher with uroporphyrin. Hematoporphyrin [14459-29-1] (with 2 carboxyl groups) also formed a complex with chloroquine, but the interaction was weaker than that with coproporphyrin. [on SciFinder(R)]

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Authors

  • Brian C. Shanley

  • Kieran Clarke

  • Donald J. Winzor

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