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Chloroquine [54-05-7] interacted with both uroporphyrin [26316-36-9] and coproporphyrin [14643-66-4], and plots of difference spectroscopy data indicated a 1:1 stoichiometry for both porphyrin-chloroquine complexes. Thus, the stoichiometry of the interaction was not affected by the presence of 4 carboxyl groups on coproporphyrin and 8 on uroporphyrin, although the strength of the interaction was ∼3-fold higher with uroporphyrin. Hematoporphyrin [14459-29-1] (with 2 carboxyl groups) also formed a complex with chloroquine, but the interaction was weaker than that with coproporphyrin. [on SciFinder(R)]




Shanley, B. C., Clarke, K., & Winzor, D. J. (1985). Evaluation of the stoichiometry and strength of chloroquine-porphyrin interactions by difference spectroscopy. Biochemical Pharmacology, 34(1), 141–142. https://doi.org/10.1016/0006-2952(85)90112-1

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