The selective tachykinin NK1 receptor agonists, septide ([Glp6,Pro9]substance P-(6-11)) and [Sar9]substance P sulfone, both produced concentration-dependent contraction of the circular muscle of the guinea-pig ileum (EC50 values 36 and 84 pM, respectively). The potent and selective NK1 receptor antagonist (±)CP 96, 345 antagonized and the response to septide with significantly higher affinity than it did the response to [Sar9]substance P sulfone (pA2 values 9.24 and 8.17, respectively) without modifying the response to the selective NK2 receptor agonist, [β-Ala8]neurokinin A-(4-10). These findings indicate that the septide-sensitive receptor in the circular muscle of the guinea-pig ileum is recognized with high affinity by the NK1 receptor selective antagonist (±)-CP 96,345. © 1993.
Maggi, C. A., Patacchini, R., Meini, S., & Giuliani, S. (1993). Evidence for the presence of a septide-sensitive tachykinin receptor in the circular muscle of the guinea-pig ileum. European Journal of Pharmacology, 235(2–3), 309–311. https://doi.org/10.1016/0014-2999(93)90152-8