Existence of a polar digitalis-like factor in mammalian hypothalamus

  • Goto A
  • Yamada K
  • Ishii M
 et al. 
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We were able to partially purify a polar digitalis-like factor from rat and bovine hypothalami based on the capacity to inhibit [3H]ouabain binding to intact human erythrocytes. This factor was characterized in reference to the digitalis-like factor that we have isolated and reported on. Hypothalamic factor shared digitalis-like activities and physicochemical properties with the one derived from human urine and mammalian plasma. These findings strongly suggest that a polar digitalis-like factor identical to the circulatory factor does exist in mammalian hypothalamus. © 1989.

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  • A. Goto

  • K. Yamada

  • M. Ishii

  • M. Yoshioka

  • T. Ishiguro

  • C. Eguchi

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