Expression of EphA4 in developing inner ears of the mouse and guinea pig

23Citations
Citations of this article
10Readers
Mendeley users who have this article in their library.
Get full text

Abstract

The expression of EphA4, an Eph-class receptor tyrosine kinase, was determined by immunohistochemistry in developing inner ears of the mouse and the guinea pig. In the mouse, EphA4 expression was visible in the fibroblasts of the spiral ligament and in the structures that were to become the osseous spiral lamina. Cochlear nerve ganglion cells expressed ephrin-B2, and the modiolus expressed mRNA coding for ephrin-B3, both transmembrane ligands for EphA4. In contrast, in the guinea pig, cells of the cochlear nerve ganglion expressed EphA4, as did supporting cells of the organ of Corti (Hensen's cells and inner pillar cells). There was also some expression in fibroblasts of the spiral ligament but none in the structures that were to become the osseous spiral lamina. It is suggested that in the mouse, EphA4 may help direct the cochlear innervation towards the organ of Corti by a repulsive interaction, but that this is highly species dependent. Copyright (C) 2000 Elsevier Science B.V.

Cite

CITATION STYLE

APA

Van Heumen, W. R. A., Claxton, C., & Pickles, J. O. (2000). Expression of EphA4 in developing inner ears of the mouse and guinea pig. Hearing Research, 139(1–2), 42–50. https://doi.org/10.1016/S0378-5955(99)00158-6

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free