Expression of stereotyped behaviour requires stimulation of nigral D1 dopamine receptors

  • Lee C
  • Double K
  • Crocker A
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Abstract

Dopamine receptors in the pars reticulata of the substantia nigra were inactivated following bilateral injections of N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ). Loss of D1, but not D2, receptors was associated with a significant decrease in the incidence of stereotyped head-down sniffing elicited by the mixed D1/D2receptor agonist, apomorphine. The results support the hypothesis that D1receptors in the substantia nigra are necessary for the expression of dopamine mediated stereotyped behaviour. © 1995 Elsevier Science B.V. All rights reserved.

Author-supplied keywords

  • Autoradiography
  • Behaviour
  • Dopamine receptor
  • N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline
  • Substantia nigra

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Authors

  • C. Y. Lee

  • K. L. Double

  • A. D. Crocker

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