Dopamine receptors in the pars reticulata of the substantia nigra were inactivated following bilateral injections of N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ). Loss of D1, but not D2, receptors was associated with a significant decrease in the incidence of stereotyped head-down sniffing elicited by the mixed D1/D2receptor agonist, apomorphine. The results support the hypothesis that D1receptors in the substantia nigra are necessary for the expression of dopamine mediated stereotyped behaviour. © 1995 Elsevier Science B.V. All rights reserved.
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