Expression of stereotyped behaviour requires stimulation of nigral D1 dopamine receptors

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Abstract

Dopamine receptors in the pars reticulata of the substantia nigra were inactivated following bilateral injections of N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ). Loss of D1, but not D2, receptors was associated with a significant decrease in the incidence of stereotyped head-down sniffing elicited by the mixed D1/D2 receptor agonist, apomorphine. The results support the hypothesis that D1 receptors in the substantia nigra are necessary for the expression of dopamine mediated stereotyped behaviour. © 1995 Elsevier Science B.V. All rights reserved.

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Lee, C. Y., Double, K. L., & Crocker, A. D. (1995). Expression of stereotyped behaviour requires stimulation of nigral D1 dopamine receptors. Brain Research, 681(1–2), 205–208. https://doi.org/10.1016/0006-8993(95)00263-P

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