A facile annelation of pyridines with nitriles of α,α-acetylenic γ-hydroxyacids

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Abstract

Pyridines are readily annelated with nitriles of α,β-acetylenic γ-hydroxyacids under mild conditions (ambient temperature, no catalyst, no solvent) to give new condensed dihydropyridine systems, 4-cyanomethylidene-1,3-oxazolidine[3,2-a]-1,2-dihydropyridines in 75-83% yields. © 2002 Elsevier Science Ltd. All rights reserved.

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Trofimov, B. A., Andriyankova, L. V., Zhivet’ev, S. A., Mal’kina, A. G., & Voronov, V. K. (2002). A facile annelation of pyridines with nitriles of α,α-acetylenic γ-hydroxyacids. Tetrahedron Letters, 43(6), 1093–1096. https://doi.org/10.1016/S0040-4039(01)02332-2

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