A facile annelation of pyridines with nitriles of α,α-acetylenic γ-hydroxyacids

  • Trofimov B
  • Andriyankova L
  • Zhivet’ev S
 et al. 
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Abstract

Pyridines are readily annelated with nitriles of α,β-acetylenic γ-hydroxyacids under mild conditions (ambient temperature, no catalyst, no solvent) to give new condensed dihydropyridine systems, 4-cyanomethylidene-1,3-oxazolidine[3,2-a]-1,2-dihydropyridines in 75-83% yields. © 2002 Elsevier Science Ltd. All rights reserved.

Author-supplied keywords

  • 4-Cyanomethylidene-1, 3-oxazolidine[3,2-a]-1, 2-dihydropyridines
  • Nitriles of α,β-acetylenic γ-hydroxyacids
  • Pyridines

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Authors

  • Boris A. Trofimov

  • Ludmila V. Andriyankova

  • Sergei A. Zhivet’ev

  • Anastasiya G. Mal’kina

  • Vladimir K. Voronov

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