Failure of d-cycloserine to reverse cognitive disruption induced by scopolamine or phencylidine in primates

  • Rupniak N
  • Duchnowski M
  • Tye S
 et al. 
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The partial glycine agonist d-cycloserine may be of therapeutic use as a cognitive enhancer. We examined the ability of d-cycloserine (3-14 mg/kg i.m.) to reverse cognitive impariments induced by scopolamine (0.03 mg/kg) or PCP (0.25 mg/kg). There was no evidence for a dose-related improvement in visuospatial memory using retention intervals of 2,10 or 20 sec. A possible explanation for these findings is that central glycine function cannot be adequately increased using systemic administration of d-cycloserine in this dose range. © 1992.

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  • N. M.J. Rupniak

  • M. Duchnowski

  • S. J. Tye

  • G. Cook

  • S. D. Iversen

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