Failure of d-cycloserine to reverse cognitive disruption induced by scopolamine or phencylidine in primates

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Abstract

The partial glycine agonist d-cycloserine may be of therapeutic use as a cognitive enhancer. We examined the ability of d-cycloserine (3-14 mg/kg i.m.) to reverse cognitive impariments induced by scopolamine (0.03 mg/kg) or PCP (0.25 mg/kg). There was no evidence for a dose-related improvement in visuospatial memory using retention intervals of 2,10 or 20 sec. A possible explanation for these findings is that central glycine function cannot be adequately increased using systemic administration of d-cycloserine in this dose range. © 1992.

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Rupniak, N. M. J., Duchnowski, M., Tye, S. J., Cook, G., & Iversen, S. D. (1992). Failure of d-cycloserine to reverse cognitive disruption induced by scopolamine or phencylidine in primates. Life Sciences, 50(25), 1959–1962. https://doi.org/10.1016/0024-3205(92)90525-T

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