First hydroxamate inhibitors for carboxypeptidase A. N-acyl-N-hydroxy- β-phenylalanine S

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Abstract

A series of N-acyl-N-hydroxy-β-Phe were designed, synthesized, and shown to have potent inhibitory activity for carboxypeptidase A (CPA). They are the first examples of CPA inhibitors having a hydroxamate functionality.

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Kim, D. H., & Jin, Y. (1999). First hydroxamate inhibitors for carboxypeptidase A. N-acyl-N-hydroxy- β-phenylalanine S. Bioorganic and Medicinal Chemistry Letters, 9(5), 691–696. https://doi.org/10.1016/S0960-894X(99)00055-4

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