Fmoc-protected tropane-based amino acids for peptide structure-function studies

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Abstract

Cyclic amino acids derived from the tropane alkaloid nucleus have been prepared and incorporated into synthetic peptides. These conformationally constrained β-amino acids hold considerable potential for use in the development of novel, synthetic analogues of biologically active peptides.

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Thompson, P. E., & Hearn, M. T. W. (1997). Fmoc-protected tropane-based amino acids for peptide structure-function studies. Tetrahedron Letters, 38(16), 2907–2910. https://doi.org/10.1016/S0040-4039(97)00500-5

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