Folate and cobalamin uptake by human placenta in complicated pregnancies: Prematurity, preeclampsia and fetal neural tube defects

  • Melo G
  • Trugo N
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Abstract

The purpose of the present study was to evaluate whether folate and cobalamin uptakes by microvillous membrane vesicles (MV) from human placenta are affected in pregnancy complications such as prematurity, preeclampsia, and fetal neural tube defects. MMVs were obtained from pooled placental samples from adult women with uncomplicated full-term gestations (n=4), premature delivery (n=3), preeclampsia (n=3), and fetal neural tube defects (n=2). Uptake of cobalamin bound to transcobalamin (TC) was several times higher than the uptake of free cobalamin or cobalamin bound to haptocorrin. TC-cobalamin and folate uptakes by placental MMV were not impaired in preeclampsia, but TC-cobalamin uptake was higher (p

Author-supplied keywords

  • Cobalamin
  • Folate
  • Neural tube defects
  • Placenta
  • Preeclamsia
  • Prematurity

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Authors

  • Gláucia J O Melo

  • Nadia M F Trugo

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