Footshock-analgesia: Prevention by behavioural manipulation but not by naloxone

  • Rodgers R
  • Deacon R
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The effects of behavioural manipulation and naloxone administration on footshock-analgesia were investigated. Acute exposure of single rats to footshock resulted in a significant elevation in tail-flick latencies whilst paired animals, which fought in response to shock, did not display such analgesia. Naloxone hydrochloride (5 mg/kg), administered prior to footshock, failed to prevent the shock-induced increases in latencies. These results suggest that (a) the particular manner in which rats respond to footshock is a critical determinant of the analgesic effects of shock and (b) it is unlikely that naloxone-sensitive opiate receptors are involved in this footshock analgesia or its prevention by behavioural manipulation. © 1981.

Author-supplied keywords

  • Analgesia
  • Fighting
  • Footshock
  • Naloxone
  • Opiates
  • Rats

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