Formation and cleavage of thiohydantoin ring catalysed by trypsin

Abstract

The intramolecular dehydratation of phenyl thiocarbamyl amino acid to the corresponding thiohydantoin and the reverse hydrolytic reaction are specifically and separatelycatalyzed by trypsin at two different pH values when l-Arg derivatives are concerned. These substrates disclose the ability of trypsin to catalyze unexpected synthetic and hydrolytic reactions. © 1980.