Free prolactin determinations in hyperprolactinemic men with suspicion of macroprolactinemia

  • Sapin R
  • Gasser F
  • Grucker D
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Background: The Elecsys® prolactin (PRL) assay reacts more strongly with macroprolactin than the Centaur® PRL assay. We evaluated Elecsys direct and free PRL measurements vs. Centaur direct PRL measurements, in sera with and without macroprolactin. Methods: PRL was measured using Elecsys and Centaur direct assays and the Elecsys assay in the supernatant obtained after PEG precipitation (free PRL) in 34 sera from 34 hyperprolactinemic male subjects (Elecsys direct PRL > 434 mIU/l) classified, according to the PRL recovery after PEG precipitation, as: negative, i.e. without predominant macroprolactin (recovery %>50, n = 12), positive (recovery %

Author-supplied keywords

  • Hyperprolactinemia
  • Immunoassay
  • Macroprolactin
  • Polyethylene glycol precipitation
  • Prolactin

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  • Rémy Sapin

  • Françoise Gasser

  • Daniel Grucker

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