Gastroprotective activity of the novel proton pump inhibitor lansoprazole in the rat

  • Morini G
  • Grandi D
  • Arcari M
 et al. 
  • 5


    Mendeley users who have this article in their library.
  • 9


    Citations of this article.


1. 1. The protective activity of lansoprazole was evaluated on gastric mucosal lesions induced by intragastric 25% NaCI (1 ml/rat for 1 hr) and by indomethacin (20 mg/kg for 6 hr) in the rat and compared with that of omeprazole. 2. 2. Lansoprazole (3, 10 and 30 μmol/kg i.g.) dose-dependently prevented the formation of indomethacin-induced lesions, the inhibition being 99% at the highest dose. Omeprazole, 10 μmol/kg i.g., enhanced the damage by indomethacin while higher doses caused a reduction, lesion index being reduced by 98% at 100 μmol/kg. 3. 3. Histologically in lansoprazole- as well as in omeprazole-pretreated rats, indomethacin-induced necrosis of the mucosa was absent, luminal epithelium being intact. 4. 4. Lansoprazole (30, 100 and 300 μmol/kg) and omeprazole (30, 100 and 300 μmol/kg) dose-dependently reduced the formation of lesions by hypertonic saline. 5. 5. Present results indicate that lansoprazole and omeprazole protect the gastric mucosa in different experimental models of gastric ulceration. © 1995.

Author-supplied keywords

  • Lansoprazole
  • gastroprotection
  • omeprazole

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • Giuseppina Morini

  • Daniela Grandi

  • Maria Luisa Arcari

  • Giulio Bertaccini

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free