Gender difference in BK channel expression in amygdala complex of rat brain

  • Ohno A
  • Ohya S
  • Yamamura H
 et al. 
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Abstract

The expression of large-conductance Ca 2+ -activated K + (BK) channel protein in amygdala complex was higher in adult (8-10 weeks old) male rats than in female. Castration at 4-6 weeks old significantly reduced BK channel expression in amygdala to the level similar to that in female. Immunocytochemical analyses of pyramidal-like neurons isolated from amygdala revealed that somas with relatively large size were highly immunoreactive to both anti-androgen receptor (AR) and anti-BK channel antibodies, while those with smaller size were not. The double-immunopositive neurons were dominant (60%) among pyramidal-like neurons isolated from amygdala of male rats but rare among those from female. The membrane current sensitive to penitrem A, a BK channel blocker, was the major K + current component in large neurons and showed higher current-density than that in smaller ones. These results suggest the gender-dependent cell population expressing BK channels in amygdala complex and its up-regulation by AR stimulation. © 2008 Elsevier Inc. All rights reserved.

Author-supplied keywords

  • Amygdala
  • Androgen receptor
  • BK channel
  • Castration
  • Gender difference
  • Neuron
  • Rat

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Authors

  • A. Ohno

  • S. Ohya

  • H. Yamamura

  • Y. Imaizumi

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