Glucocorticoid modulation of neurotrophin expression in immortalized mouse hippocampal neurons

  • Scully J
  • Otten U
  • 4

    Readers

    Mendeley users who have this article in their library.
  • 16

    Citations

    Citations of this article.

Abstract

To see whether glucocorticoid hormones can influence the regulation of neurotrophin expression in hippocampal neurons, we have used reverse-transcription followed by polymerase chain reaction to investigate changes in the mRNA levels of nerve growth factor (NGF) and neurotrophin-3 (NT-3) in immortalized hippocampal neurons after dexamethasone application. Our results show that NGF mRNA levels rise in both embryonic and postnatal neurons, but with different time courses, while NT-3 levels rise in the embryonic but not in the postnatally derived cell line. Modulation of NT expression by glucocorticoids may therefore be developmentally regulated. © 1993.

Author-supplied keywords

  • Glucocorticoid, Regulation
  • Hippocampus
  • Nerve growth factor
  • Neurodegeneration
  • Neurotrophin-3

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Authors

  • J. Leach Scully

  • U. Otten

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free