Glucocorticoid modulation of neurotrophin expression in immortalized mouse hippocampal neurons

  • Scully J
  • Otten U
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To see whether glucocorticoid hormones can influence the regulation of neurotrophin expression in hippocampal neurons, we have used reverse-transcription followed by polymerase chain reaction to investigate changes in the mRNA levels of nerve growth factor (NGF) and neurotrophin-3 (NT-3) in immortalized hippocampal neurons after dexamethasone application. Our results show that NGF mRNA levels rise in both embryonic and postnatal neurons, but with different time courses, while NT-3 levels rise in the embryonic but not in the postnatally derived cell line. Modulation of NT expression by glucocorticoids may therefore be developmentally regulated. © 1993.

Author-supplied keywords

  • Glucocorticoid, Regulation
  • Hippocampus
  • Nerve growth factor
  • Neurodegeneration
  • Neurotrophin-3

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  • J. Leach Scully

  • U. Otten

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