The greater strength of arginine: Carboxylate over lysine carboxylate ion pairs implications for the design of novel enzymes and drugs

  • Wigley D
  • Lyall A
  • Hart K
 et al. 
  • 3

    Readers

    Mendeley users who have this article in their library.
  • 15

    Citations

    Citations of this article.

Abstract

The rational design of enzyme catalysts for chiral chemistry and of drugs which bind to proteins would be facilitated if rules for the recognition of one partner by the other could be formulated. This communication suggests and tests one generalization: arginine forms a tighter ion pair with a carboxylate group than does lysine and is always used for ion-pairs which are not broken during turnover in naturally-occurring enzymes. © 1987.

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Authors

  • Dale B. Wigley

  • Andrew Lyall

  • Keith W. Hart

  • J. John Holbrook

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free