Growth stimulation of human melanocytes: Identification and characterization of melanoma-derived melanocyte growth factor (M-McGF)

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Abstract

The melanocyte growth stimulating factor from human melanoma cells grown in vitro [Eisinger, M. et al, (1985) Science 229,984-986] has been purified and identified as a 14kDa peptide. The activity was shown to be sensitive to acid and heat treatments but resistent to reduction. The factor has strong affinity for heparin-Sepharose and was separated into two fractions by ion-exchange chromatography. Based on its properties, it is grouped in the family of heparin-binding growth factors. Identification of this growth factor will provide a tool for studies of growth regulation of normal and transformed human melanocytes. © 1987.

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Ogata, S., Furuhashi, Y., & Eisinger, M. (1987). Growth stimulation of human melanocytes: Identification and characterization of melanoma-derived melanocyte growth factor (M-McGF). Biochemical and Biophysical Research Communications, 146(3), 1204–1211. https://doi.org/10.1016/0006-291X(87)90776-5

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