Headspace gas chromatography of stimulants in urine by in-column trifluoroacetyl derivatization method

24Citations
Citations of this article
1Readers
Mendeley users who have this article in their library.
Get full text

Abstract

The analysis of stimulants in urine using a headspace gas chromatography system equipped with an in-column sample trifluoroacetylation unit was investigated. A 5-ml aliquot of urine containing stimulants was pipetted into a 20-ml autosampler vial together with 3.5 g of potassium carbonate. The vial was sealed and heated for 20 min at 80°C, then 0.8 ml of the headspace gas and N-methylbis(trifluoroacetamide) gas were injected simultaneously into the gas chromatograph equipped with a flame ionization detector and a fused-silica capillary column (DB-1, 30 m × 0.32 mm I.D., film thickness 0.25 μm), with a gas-tight syringe. Calibration graphs prepared by the absolute calibration curve method showed good linearity over the concentration range of 0.04 to 50 μg/ml for methamphetamine hydrochloride and amphetamine sulphate. The detection limits were 0.03 μg/ml for both of these compounds. © 1989.

Cite

CITATION STYLE

APA

Tsuchihashi, H., Nakajima, K., Nishikawa, M., Shiomi, K., & Takahashi, S. (1989). Headspace gas chromatography of stimulants in urine by in-column trifluoroacetyl derivatization method. Journal of Chromatography A, 467(C), 227–235. https://doi.org/10.1016/S0021-9673(01)93967-6

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free