Helicobacter mustelae lipid A structure differs from that of Helicobacter pylori

  • Thérisod H
  • Monteiro M
  • Perry M
 et al. 
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Abstract

The lipid A structure of the Gram-negative bacterium Helicobacter mustelae, a ferret gastric pathogen responsible for the onset of gastric diseases in its host, was investigated. Two variant lipid A structures were found in the same strain. One structure contained a bisphosphorylated β-(1→6)-linked D-glucosamine backbone disaccharide with hydroxytetradecanoic acid in amide linkages. Unlike the structure described for the lipid A of the related human Helicobacter pylori gastric pathogen, which contains a C1 phosphate moiety, this lipid A presented phosphate groups at both the C1 and C4′ positions, and contained no octadecanoyl fatty acid, which is present in H. pylori. The second lipid A structure had a different fatty acid composition in that 3-OH C16replaced most of the amide-linked 3-OH C14. © 2001 Federation of European Biochemical Societies.

Author-supplied keywords

  • Endotoxin
  • Helicobacter mustelae
  • Lipid A
  • Structure

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Authors

  • Hélène Thérisod

  • Mario A. Monteiro

  • Malcolm B. Perry

  • Martine Caroff

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