Helicobacter mustelae lipid A structure differs from that of Helicobacter pylori

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Abstract

The lipid A structure of the Gram-negative bacterium Helicobacter mustelae, a ferret gastric pathogen responsible for the onset of gastric diseases in its host, was investigated. Two variant lipid A structures were found in the same strain. One structure contained a bisphosphorylated β-(1→6)-linked D-glucosamine backbone disaccharide with hydroxytetradecanoic acid in amide linkages. Unlike the structure described for the lipid A of the related human Helicobacter pylori gastric pathogen, which contains a C1 phosphate moiety, this lipid A presented phosphate groups at both the C1 and C4′ positions, and contained no octadecanoyl fatty acid, which is present in H. pylori. The second lipid A structure had a different fatty acid composition in that 3-OH C16replaced most of the amide-linked 3-OH C14. © 2001 Federation of European Biochemical Societies.

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Thérisod, H., Monteiro, M. A., Perry, M. B., & Caroff, M. (2001). Helicobacter mustelae lipid A structure differs from that of Helicobacter pylori. FEBS Letters, 499(1–2), 1–5. https://doi.org/10.1016/S0014-5793(01)02496-6

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