Hemolyse et schizocytose, malabsorption et <<piege a folates>>: A propos de particularites semiologiques mal connues des carences en vitamine B12

Abstract

Introduction. - Hemolysis and red cell fragmentation accompanying vitamine B12 deficiency may misdirect the diagnosis. Signs of malabsorption and abnormalities related to folic acid metabolism characterized by discrepancies between folic acid normal serum levels and erythrocytic folic acid levels may also exist. Exegesis. - We report the occurrence of hemolysis and red cell fragmentation mimicking microangiopathic hemolytic anemia, malabsorption and folic acid deficiency in the course of vitamine B12 deficiency. Appropriate replacement therapy corrected all abnormalities. Conclusion. - An association between hemolysis, malabsorption and folic acid deficiency should lead physicians to search for signs of vitamine B12 deficiency.