Heterogeneity of glycogen synthesis upon refeeding following starvation

  • Calder P
  • Geddes R
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Abstract

1. 1. Starvation of rats for 40 hr decreased the body weight, liver weight and blood glucose concentration. The hepatic and skeletal muscle glycogen concentrations were decreased by 95% (from 410 μmol/g tissue to 16 μmol/g tissue) and 55% (from 40 μmol/g tissue to 18.5 μmol/g tissue), respectively. 2. 2. Fine structural analysis of glycogen purified from the liver and skeletal muscle of starved rats suggested that the glycogenolysis included a lysosomal component, in addition to the conventional phosphorolytic pathway. In support of this the hepatic acid α-glucosidase activity increased 1.8-fold following starvation. 3. 3. Refeeding resulted in liver glycogen synthesis at a linear rate of 40 μmol/g tissue per hr over the first 13 hr of refeeding. The hepatic glycogen store was replenished by 8 hr of refeeding, but synthesis continued and the hepatic glycogen content peaked at 24 hr (∼670 μmol/g tissue). 4. 4. Refeeding resulted in skeletal muscle glycogen synthesis at an initial rate of 40 μmol/g tissue per hr. The muscle glycogen store was replenished by 30 min of refeeding, but synthesis continued and the glycogen content peaked at 13 hr (∼50 μmol/g tissue). 5. 5. Both liver and skeletal muscle glycogen synthesis were inhomogeneous with respect to molecular size; high molecular weight glycogen was initially synthesised at a faster rate than low molecular weight glycogen. These observations support suggestions that there is more than a single site of glycogen synthesis. © 1991.

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Authors

  • Philip C. Calder

  • Robert Geddes

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