Highly chemoselective synthesis of 1,2,3,4,5-pentasubstituted cyclohexanols under solvent-free condition

  • Luo X
  • Shan Z
  • 2


    Mendeley users who have this article in their library.
  • 14


    Citations of this article.


Acetophenone reacted with a series of aromatic aldehydes with grinding under catalysis of a double-component solid base system consisting of NaOH and K2CO3to furnish highly chemoselectively 1,2,3,4,5-pentasubstituted cyclohexanols in 80-95% yield, and their composition and structure are identified by spectral technologies and single crystal X-ray diffraction analysis, and a possible mechanism of the formation was suggested. © 2006 Elsevier Ltd. All rights reserved.

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • Xinxiang Luo

  • Zixing Shan

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free