Hybrid modeling of electrical and optical behavior in the heart

  • Roth B
  • Pertsov A
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Abstract

Optical mapping of transmembrane potential using voltage-sensitive dyes
has revolutionized cardiac electrophysiology by enabling the
visualization of electrical excitation waves in the heart. However, the
interpretation of the optical mapping data is complicated by the fact
that the optical signal arises not just from the Surface, but also from
some depth into the heart wall. Here, we review modeling efforts, in
which the diffusion of photons is incorporated into the computer
simulations of cardiac electrical activity ({''}hybrid{''} modeling),
with the goal of improving our understanding of optical signals. We
discuss the major accomplishments of hybrid modeling which include: (i)
the explanation of the optical action potential upstroke morphology and
prediction of its dependence on the subsurface wave front angle, (ii)
the unexpectedly low magnitudes of optically recorded Surface potentials
during electrical shocks, and (iii) the ``depolarization{''} of the core
of the spiral wave and odd dual-humped optical action potentials during
reentrant activation. We critically examine current optical mapping
techniques and controversies in our understanding of electroporation
during defibrillation. Finally, we provide a brief overview of recent
theoretical studies aimed at extending optical mapping techniques for
imaging intramural excitation to include transillumination imaging of
scroll wave filaments and depth-resolved optical tomographic methods.
(C) 2009 Elsevier B.V. All rights reserved.

Author-supplied keywords

  • Optical mapping; Hybrid modeling; Cardiac; Photon

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Authors

  • Bradley J Roth

  • Arkady M Pertsov

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