The human tyrosinase-related protein 2 (TRP-2) gene promoter contains a cis-regulatory element (positions -447 to -416), termed DOPAchrome tautomerase distal enhancer 1 (DDE1). DDE1 functions as an enhancer in cultured melanoma cells and its core element includes a potential binding site for transcription factors containing a high-mobility-group domain. This core element is bound in vitro by multiple nuclear proteins, which are preferentially expressed in melanoma cells. DDE1 represents a composite enhancer that may be involved in melanocyte-specific transcription of the human TRP-2 gene. Copyright (C) 2000 Elsevier Science B.V.
Amae, S., Yasumoto, K. ichi, Takeda, K., Udono, T., Takahashi, K., & Shibahara, S. (2000). Identification of a composite enhancer of the human tyrosinase-related protein 2/DOPAchrome tautomerase gene. Biochimica et Biophysica Acta - Gene Structure and Expression, 1492(2–3), 505–508. https://doi.org/10.1016/S0167-4781(00)00125-1