Identification of a composite enhancer of the human tyrosinase-related protein 2/DOPAchrome tautomerase gene

17Citations
Citations of this article
3Readers
Mendeley users who have this article in their library.
Get full text

Abstract

The human tyrosinase-related protein 2 (TRP-2) gene promoter contains a cis-regulatory element (positions -447 to -416), termed DOPAchrome tautomerase distal enhancer 1 (DDE1). DDE1 functions as an enhancer in cultured melanoma cells and its core element includes a potential binding site for transcription factors containing a high-mobility-group domain. This core element is bound in vitro by multiple nuclear proteins, which are preferentially expressed in melanoma cells. DDE1 represents a composite enhancer that may be involved in melanocyte-specific transcription of the human TRP-2 gene. Copyright (C) 2000 Elsevier Science B.V.

Cite

CITATION STYLE

APA

Amae, S., Yasumoto, K. ichi, Takeda, K., Udono, T., Takahashi, K., & Shibahara, S. (2000). Identification of a composite enhancer of the human tyrosinase-related protein 2/DOPAchrome tautomerase gene. Biochimica et Biophysica Acta - Gene Structure and Expression, 1492(2–3), 505–508. https://doi.org/10.1016/S0167-4781(00)00125-1

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free