Identification of a mannose-acetate-specific 87-kDa receptor responsible for human NK and LAK activity

  • Hauer J
  • Voetsch W
  • Alfred Anderer F
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Abstract

Target cell recognition and cytotoxicity of human CD56+NK and LAK cells is readily inhibited by acetylated mannose. Two respective NK cell receptor candidates were isolated from human leukocyte lysates by mannose acetate affinity chromatography. The 87-kDa receptor showed sequence homologies with lactoferrin and the 59-kDa receptor represented a complex of two Ca-binding proteins MRP-8 and MRP-14 reportedly expressed only by cells of myeloid origin. The 87-kDa receptor exhibited heterogeneity in isoelectric focusing and behaved entirely differently from lactoferrin. Preincubation of tumor target cells with the 87-kDa receptor inhibited competitively target cell recognition and cytotoxicity of human CD56+NK and LAK cells. © 1994.

Author-supplied keywords

  • Acetylated mannose
  • Human NK and LAK cytotoxicity
  • Lactoferrin sequence homology
  • NK cell receptor

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Authors

  • Jochen Hauer

  • Walter Voetsch

  • F. Alfred Anderer

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