Identification of a mannose-acetate-specific 87-kDa receptor responsible for human NK and LAK activity

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Abstract

Target cell recognition and cytotoxicity of human CD56+NK and LAK cells is readily inhibited by acetylated mannose. Two respective NK cell receptor candidates were isolated from human leukocyte lysates by mannose acetate affinity chromatography. The 87-kDa receptor showed sequence homologies with lactoferrin and the 59-kDa receptor represented a complex of two Ca-binding proteins MRP-8 and MRP-14 reportedly expressed only by cells of myeloid origin. The 87-kDa receptor exhibited heterogeneity in isoelectric focusing and behaved entirely differently from lactoferrin. Preincubation of tumor target cells with the 87-kDa receptor inhibited competitively target cell recognition and cytotoxicity of human CD56+NK and LAK cells. © 1994.

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Hauer, J., Voetsch, W., & Alfred Anderer, F. (1994). Identification of a mannose-acetate-specific 87-kDa receptor responsible for human NK and LAK activity. Immunology Letters, 42(1–2), 7–12. https://doi.org/10.1016/0165-2478(94)90027-2

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