Immune response to intranasal and intraperitoneal immunization with Kaposi's sarcoma-associated herpesvirus in mice

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Abstract

A vaccine for Kaposi's sarcoma-associated herpesvirus (KSHV) is not currently available. To obtain the fundamental data in animals for vaccine development, KSHV particles were immunized to Balb/c mice through intraperitoneal and intranasal routes in the present study. Intranasal immunization with KSHV induced IgA to KSHV in not only serum, but also nasal wash fluid and saliva. A neutralization assay using recombinant KSHV that expressed green fluorescent protein revealed that nasal wash fluid and saliva from the KSHV-immunized mice neutralized KSHV infection to human embryonic kidney 293 cells in vitro in a dose-dependent manner to KSHV copies immunized. The serum and nasal wash fluid of KSHV-encoded K8.1 protein-immunized mice neutralized KSHV infection to 293 cells in vitro. These data suggest a possibility of mucosal vaccine for prophylaxis of KSHV infection. © 2010 Elsevier Ltd. All rights reserved.

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Sakamoto, K., Asanuma, H., Nakamura, T., Kanno, T., Sata, T., & Katano, H. (2010). Immune response to intranasal and intraperitoneal immunization with Kaposi’s sarcoma-associated herpesvirus in mice. Vaccine, 28(19), 3325–3332. https://doi.org/10.1016/j.vaccine.2010.02.091

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