Antibodies against human IgM were sought by hemagglutination with a panel of proteins including 19 Waldenstrom macroglobulins. The 620 sera tested included normal blood donors of different races and patients with various forms of immune deficiency and their relatives. Anti-IgM antibodies were detected in 50 subjects (8.1%) at a titer of 1:4 or greater; they included 30 subjects who were clinically normal, 9 with recurrent infections, 4 with ataxia telangiectasia, 3 with Wiskott-Aldrich syndrome, 2 with acquired hypogammaglobulinemia, and one each with chronic active hepatitis, hemophilia, and reactions to immune serum globulin. Anti-IgM antibodies were found in 23.8% of immunodeficient subjects and 1.6% of normal blood donors; 30 subjects with anti-IgM antibodies had a decrease in at least one serum immunoglobulin. There was no association between anti-IgM antibodies and other autoantibodies and the biological significance of these antibodies is not clear. © 1973.
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