Immunobiology of human anti-IgM iso-antibodies. I. Clinical and serological studies

3Citations
Citations of this article
7Readers
Mendeley users who have this article in their library.
Get full text

Abstract

Antibodies against human IgM were sought by hemagglutination with a panel of proteins including 19 Waldenstrom macroglobulins. The 620 sera tested included normal blood donors of different races and patients with various forms of immune deficiency and their relatives. Anti-IgM antibodies were detected in 50 subjects (8.1%) at a titer of 1:4 or greater; they included 30 subjects who were clinically normal, 9 with recurrent infections, 4 with ataxia telangiectasia, 3 with Wiskott-Aldrich syndrome, 2 with acquired hypogammaglobulinemia, and one each with chronic active hepatitis, hemophilia, and reactions to immune serum globulin. Anti-IgM antibodies were found in 23.8% of immunodeficient subjects and 1.6% of normal blood donors; 30 subjects with anti-IgM antibodies had a decrease in at least one serum immunoglobulin. There was no association between anti-IgM antibodies and other autoantibodies and the biological significance of these antibodies is not clear. © 1973.

Cite

CITATION STYLE

APA

Wells, J. V., Bleumers, J. F., & Fudenberg, H. G. (1973). Immunobiology of human anti-IgM iso-antibodies. I. Clinical and serological studies. Clinical Immunology and Immunopathology, 1(2), 257–269. https://doi.org/10.1016/0090-1229(73)90026-3

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free