Immunologic Preparations

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This chapter provides an overview of immunologic preparations. One of the preparations discussed is prophylactic vaccination. The case of a 3-year-old girl who survived generalized BCG infection. It is suggested that in this case children develop a BCG-osis in the absence of an obvious immunologic defect, a defect of the macrophage function may exist. Another case of abnormal macrophage and T lymphocyte function in a fatal BCG infection is also reported. Therapeutic use of Corynebacterium parvumin in patients with disseminated melanoma is discussed. Hepatitis B vaccines are still in an experimental stage. A recent field test with a French vaccine did not show serious side effects. Local reactions, such as sore arm, erythema and induration, occurred in equally low frequency in vaccine recipients and placebo recipients. General reactions, like nausea and fatigue, were scarce and showed hardly higher frequencies in the vaccine group than in the controls. Poliomyelitis was diagnosed in a 14- month-old female infant with agammaglobulinemia. She had received 2 doses of trivalent oral poliovaccine at the age of 6 and 12 months respectively. Poliovirus type 2 was isolated from the stool specimen but no antibodies against this virus were detected. Poliovirus type 2 is assumed to have a greater ability to produce viremia than the other 2 types, a fact which may be responsible for the predominance of type 2 disease in immunodeficient children. © 1982, Excerpta Medica




Hofman, B., & Lansberg, H. P. (1982). Immunologic Preparations. Side Effects of Drugs Annual, 6(C), 286–290.

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