This chapter discusses the immunology and pathogenesis of African animal trypanosomiasis. Hemoparasite infections represent some of the most important uncontrolled diseases of humans and animals in the tropics and other parts of the world. These conditions—for example, malaria and trypanosomiasis of humans and babesiosis, anaplasmosis, trypanosomiasis, and theileriosis of animals—are especially prevalent in many developing countries and are significant constraints to livestock production and improved human health. The maladies are complex in terms of their pathogenesis and immunology. They are characterized by chronic or persistent infections in some or all infected species. African animal trypanosomiasis is characterized by a complex host–parasite relationship in which the organism evolves sophisticated mechanisms for evading the host defense mechanisms. The structural components in trypanosomes include a nucleus, kinetoplast, mitochondria, granules, filaments, and tubules. A limiting membrane encloses these structures and associated cytoplasm. External to the limiting membrane is a protein coat. © 1979, ACADEMIC PRESS.
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