Immunostimulatory and immunosuppressive factors in human cancer ascites fluids: Effect on the primary plaque-forming response in vitro

12Citations
Citations of this article
1Readers
Mendeley users who have this article in their library.
Get full text

Abstract

Immunosuppressive and immunostimulatory activity of human cancer ascitic fluids has been examined using the in vitro primary plaque-forming cell response (PFR) to sheep erythrocytes (Mishell-Dutton assay). We have prepared three fractions of ascitic fluid by precipitation with ammonium sulfate. Suppressive activity occurred in the fraction which was insoluble at 50% of saturation but not those fractions which precipitated at 30 or 80% of saturation. The fractions which were precipitated at 30 and 80% were stimulatory in the assay system. Normal human serum also had suppressive activity in the fraction precipitated at 50% of saturation but not as much as was found in ascitic fluid. Serum did not yield any fractions with stimulatory activity. © 1976.

Cite

CITATION STYLE

APA

Badger, A. M., Merluzzi, V. J., & Cooperband, S. R. (1976). Immunostimulatory and immunosuppressive factors in human cancer ascites fluids: Effect on the primary plaque-forming response in vitro. Cellular Immunology, 27(1), 126–130. https://doi.org/10.1016/0008-8749(76)90161-1

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free