An improved method for analysis of technetium radiolabeled antibody by size exclusion HPLC

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Abstract

A quantitative radio HPLC method for the analysis of radiolabeled99mTc compounds, in particular labeled antibodies or proteins, is described. The method is based on the quantitative re-oxidation of the reduced column absorbed99mTc species to pertechnetate using hydrogen peroxide. The pertechnetate is quantitatively eluted from the column. The method can be used as a stand alone technique for determining the true radiolabeling yield of labeled proteins/antibodies. The method has been automated for routine use and the typical analysis time is 30 min. © 1994.

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Muddukrishna, S. N., Jorge, P., Machner, W., Sykes, T. R., & Noujaim, A. A. (1994). An improved method for analysis of technetium radiolabeled antibody by size exclusion HPLC. Applied Radiation and Isotopes, 45(10), 1009–1019. https://doi.org/10.1016/0969-8043(94)90169-4

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